Article
Establishment and characterization of a novel polarized MDCK epithelial cellular model for CFTR studies.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology - 1 Jan 2005
Mendes Filipa, Wakefield John, Bachhuber Tanja, Barroso Margarida, Bebok Zsuzsa, Penque Deborah, Kunzelmann Karl, Amaral Margarida D
Abstract excerpt
F508del is the most common mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene that is responsible for the genetic disease Cystic Fibrosis (CF). It results in a major failure of CFTR to traffic to the apical membrane of epithelial cells, where it should function as a chloride (Cl-) channel. Most studies on localization, processing and cellular trafficking of wild-type (wt) and...
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