Partial correction of cystic fibrosis defects with PLGA nanoparticles encapsulating curcumin.

Abstract excerpt

Cystic fibrosis (CF) is a common life threatening genetic disease (incidence: approximately 1 in 2500 live births). CF is caused by mutations in CFTR, a chloride channel involved in epithelial secretion of fluid and electrolytes. The most common mutation entails the deletion of a phenylalanine in position 508 that causes protein misfolding and abnormal CFTR processing. The DeltaF508 mutation accounts for...

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