ICOSL in host defense at epithelial barriers: lessons from ICOSLG deficiency.

Abstract excerpt

Autosomal recessive mutations in Inducible T Cell Costimulator Ligand (ICOSLG) result in a combined immunodeficiency syndrome of humans, saliently marked by recurrent respiratory tract infections and significant disease with DNA-based viruses at epithelial barriers, including human papillomavirus (HPV). These features are also seen in persons with loss of function of the complementary gene, ICOS. The infection...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Disease Resistance
• Share to Disease Susceptibility
• Share to Epithelium