Diagnostic relevance of overexpressions of PKC-θ and DOG-1 and KIT/PDGFRA gene mutations in extragastrointestinal stromal tumors: a Korean six-centers study of 28 cases.

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Diagnostic relevance of overexpressions of PKC-θ and DOG-1 and KIT/PDGFRA gene mutations in extragastrointestinal stromal tumors: a Korean six-centers study of 28 cases.

Anticancer research - 1 Mar 2012

Kim Kyung-Hee, Nelson Scott D, Kim Dong-Hoon, Choi Kyung Un, Kim Su Jin, Min Kyueng-Whan, Jang Ki-Seok, Paik Seung Sam, Oh Young-Ha, Chae Seoung Wan, Sohn Jin Hee, Kim Hong Joo, Cho Yong Kyun, Kim Byung Ik, Park Dong Il, Sohn Chong Il, Oh Sukjoong, Choi Seon Hyeong, Choi Yoon Jung, Woo Hee-Yeon, Park Yong Lai, Park Se Jin, Lee Sang Hyuk, Ryu Seungho, DO Sung-Im, Kang Guhyun, Kim Kyungeun, Cho Young Hye, Pyo Jung-Soo

Abstract excerpt

BACKGROUND: We investigated the clinicopathological and immunohistochemical characteristics, genetic aberrations and prognostic factors in 28 patients with extragastrointestinal stromal tumors (EGISTs) from six centers in South Korea. PATIENTS AND METHODS: Immunohistochemistry was performed for c-KIT (CD117), PKC-θ (protein kinase C theta), DOG-1 (discovered on GIST-1), CD34, alpha-smooth muscle actin (α-SMA),...

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PMID: 22399613

Genes

KIT
PDGFRA

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