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Article

Enhancement of androgen action in the kidneys of transgenic mice harboring the mutant human UMOD gene.

Journal of pharmacological sciences - 1 Jan 2011

Takiue Yuichi, Hosoyamada Makoto, Kimura Masaki, Saito Hidetsugu

Abstract excerpt

Uromodulin storage diseases are characterized by hyperuricemia of underexcretion type and renal insufficiency. Although these diseases are caused by mutations in the UMOD gene that encodes the kidney-specific glycoprotein uromodulin, the effect of uromodulin mutation on the kidney has not been clearly established. In this study, we investigated the effect by comparing transgenic mice expressing human uromodulin...

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Source

Identifiers

PMID: 21358122
DOI: 10.1254/jphs.10240fp

Genes

UMOD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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