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Article

Production and characterization of transgenic mice harboring mutant human UMOD gene.

Nucleosides, nucleotides & nucleic acids - 1 Jun 2008

Takiue Yuichi, Hosoyamada Makoto, Yokoo Takuya, Kimura Masaki, Ochiai Manami, Kaneko Kiyoko, Ichida Kimiyoshi, Hosoya Tatsuo, Shibasaki Toshiaki

Abstract excerpt

Familial juvenile hyperuricemic nephropathy is caused by mutations in the UMOD gene encoding uromodulin. A transgenic mouse model was developed by introducing a human mutant UMOD (C148W) cDNA under control of the mouse umod promoter. Uromodulin accumulation was observed in the thick ascending lim...

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Source

Identifiers

PMID: 18600511
DOI: 10.1080/15257770802136065

Genes

UMOD

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18600511-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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