Article
A mouse model for inherited renal fibrosis associated with endoplasmic reticulum stress.
Disease models & mechanisms - 1 Jun 2017
Piret Sian E, Olinger Eric, Reed Anita A C, Nesbit M Andrew, Hough Tertius A, Bentley Liz, Devuyst Olivier, Cox Roger D, Thakker Rajesh V
Abstract excerpt
Renal fibrosis is a common feature of renal failure resulting from multiple etiologies, including diabetic nephropathy, hypertension and inherited renal disorders. However, the mechanisms of renal fibrosis are incompletely understood and we therefore explored these by establishing a mouse model for a renal tubular disorder, referred to as autosomal dominant tubulointerstitial kidney disease (ADTKD) due to...
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