Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Endoplasmic reticulum stress in UMOD-related kidney disease: a human pathologic study.

American journal of kidney diseases : the official journal of the National Kidney Foundation - 1 Jan 2012

Adam Julien, Bollée Guillaume, Fougeray Sophie, Noël Laure-Hélène, Antignac Corinne, Knebelman Bertrand, Pallet Nicolas

Abstract excerpt

Mutations of the UMOD gene, which encodes the uromodulin protein, are associated with tubulointerstitial nephritis and hyperuricemia. UMOD mutations impair uromodulin folding, resulting in its retention within the endoplasmic reticulum (ER) of renal tubular cells. The aim of this study was to investigate whether mutant uromodulin accumulation in epithelial tubular cells is associated with ER stress. We...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adolescent
Share to Child

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Endoplasmic Reticulum Chaperone BiP

Share to Endoplasmic Reticulum Stress

Share to Kidney Diseases

Share to Mutation

Share to Uromodulin

Share to Young Adult

Source

Identifiers

PMID: 21978600
DOI: 10.1053/j.ajkd.2011.08.014

Genes

UMOD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Endoplasmic reticulum stress in UMOD-related kidney disease: a human pathologic study.PMID 21978600Read ↗

Mutant uromodulin expression leads to altered homeostasis of the endoplasmic reticulum and activates the unfolded protein response.Semantic proximity Read ↗

Uromodulin-associated kidney disease.Semantic proximity Read ↗

Uromodulin-related autosomal-dominant tubulointerstitial kidney disease—pathogenetic insights based on a caseSemantic proximity Read ↗

Early involvement of cellular stress and inflammatory signals in the pathogenesis of tubulointerstitial kidney disease due to UMOD mutations.Semantic proximity Read ↗

A mouse model for inherited renal fibrosis associated with endoplasmic reticulum stress.Semantic proximity Read ↗

Upregulation of C/EBP Homologous Protein induced by ER Stress Mediates Epithelial to Myofibroblast Transformation in ADTKD-UMOD.Semantic proximity Read ↗

Allelic effects on uromodulin aggregates drive autosomal dominant tubulointerstitial kidney disease.Semantic proximity Read ↗

Allelic and Gene Dosage Effects Involving Uromodulin Aggregates Drive Autosomal Dominant Tubulointerstitial Kidney DiseaseSemantic proximity Read ↗

Uromodulin biology and pathophysiology--an update.Semantic proximity Read ↗

Unveiling the Hidden Power of Uromodulin: A Promising Potential Biomarker for Kidney DiseasesSemantic proximity Read ↗

Defective Intracellular Trafficking of Uromodulin Mutant IsoformsSemantic proximity Read ↗

[Kidney diseases associated with uromodulin (Tamm-Horsfall protein)].Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.