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Article

Partial loss of epithelial phenotype in kindlin-1-deficient keratinocytes.

The American journal of pathology - 1 Apr 2012

Qu Haiyan, Wen Tingting, Pesch Monika, Aumailley Monique

Abstract excerpt

Kindlin-1 is an adaptor protein that is expressed by most epithelial cells and has been implicated in integrin bidirectional signaling. Mutations in the gene encoding kindlin-1 are associated with Kindler syndrome, a recessively inherited disorder that is characterized by fragile skin. Functionally, a loss of kindlin-1 impairs the adhesion of basal keratinocytes to the extracellular matrix both in vivo and in...

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Identifiers

PMID: 22326752
DOI: 10.1016/j.ajpath.2012.01.005

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Partial loss of epithelial phenotype in kindlin-1-deficient keratinocytes.PMID 22326752Read ↗

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