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Article

Kindlin-1 Regulates Integrin Dynamics and Adhesion Turnover

11 Jun 2013

Abstract excerpt

Loss-of-function mutations in the gene encoding the integrin co-activator kindlin-1 cause Kindler syndrome. We report a novel kindlin-1-deficient keratinocyte cell line derived from a Kindler syndrome patient. Despite the expression of kindlin-2, the patient's cells display several hallmarks related to reduced function of β1 integrins, including abnormal cell morphology, cell adhesion, cell spreading, focal...

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PMID: 23776470
DOI: 10.1371/journal.pone.0065341

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