Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Altered hippocampal synaptic transmission in transgenic mice with astrocyte-targeted enhanced CCL2 expression.

Brain, behavior, and immunity - 1 Jun 2011

Nelson Thomas E, Hao Christine, Manos Jessica, Ransohoff R M, Gruol Donna L

Abstract excerpt

Elevated expression of neuroinflammatory factors in the central nervous system (CNS) contributes to the cognitive impairment in CNS disorders such as injury, disease and neurodegenerative disorders. However, information on the role of specific neuroimmune factors in normal and abnormal CNS function is limited. In this study, we investigated the effects of chronic exposure to the chemokine CCL2 on hippocampal...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Astrocytes
Share to Chemokine CCL2
Share to Electrophysiology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hippocampus

Share to Neuronal Plasticity

Share to Neurons

Share to Synapses

Share to Synaptic Transmission

Source

Open in PubMed Open full text

Identifiers

PMID: 21356306
DOI: 10.1016/j.bbi.2011.02.013
PMCID: PMC4467826

Genes

CCL2
GFAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Altered hippocampal synaptic transmission in transgenic mice with astrocyte-targeted enhanced CCL2 expression.PMID 21356306Read ↗

Alterations in microglial phenotype and hippocampal neuronal function in transgenic mice with astrocyte-targeted production of interleukin-10.Semantic proximity Read ↗

Astrocyte- and endothelial-targeted CCL2 conditional knockout mice: critical tools for studying the pathogenesis of neuroinflammation.Semantic proximity Read ↗

Pentylenetetrazole-Induced Seizures Cause Short-Term Changes in the Phenotype of Microglial and Astroglial Cells in the Hippocampus and Temporal Cortex of Young Male Wistar Rats.Semantic proximity Read ↗

Microglia-dependent presynaptic disruption in an organotypic hippocampal slice culture model of neuroinflammationSemantic proximity Read ↗

CCL2 Overexpression in the Brain Promotes Glial Activation and Accelerates Tau Pathology in a Mouse Model of Tauopathy.Semantic proximity Read ↗

CCR2 antagonism identifies blood-borne monocytes as a target for prevention of cognitive deficits after seizuresSemantic proximity Read ↗

Regulation of gene expression in experimental autoimmune encephalomyelitis indicates early neuronal dysfunctionSemantic proximity Read ↗

Mice overexpressing chemokine ligand 2 (CCL2) in astrocytes display enhanced nociceptive responses.Semantic proximity Read ↗

Structural and Functional Impact of the Transgenic Expression of Cytokines in the CNSaSemantic proximity Read ↗

Transgenic mice and cytokine actions in the brain: bridging the gap between structural and functional neuropathology1Published on the World Wide Web on 21 October 1997.1Semantic proximity Read ↗

Central nervous system inflammation and neurological disease in transgenic mice expressing the CC chemokine CCL21 in oligodendrocytes.Semantic proximity Read ↗

Tissue transglutaminase overexpression in the brain potentiates calcium-induced hippocampal damage.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.