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Article

Central nervous system inflammation and neurological disease in transgenic mice expressing the CC chemokine CCL21 in oligodendrocytes.

Journal of immunology (Baltimore, Md. : 1950) - 1 Feb 2002

Chen Shu-Cheng, Leach Michael W, Chen Yuetian, Cai Xiao-Yan, Sullivan Lee, Wiekowski Maria, Dovey-Hartman B J, Zlotnik Albert, Lira Sergio A

Abstract excerpt

To study the biological role of the chemokine ligands CCL19 and CCL21, we generated transgenic mice expressing either gene in oligodendrocytes of the CNS. While all transgenic mice expressing CCL19 in the CNS developed normally, most (18 of 26) of the CCL21 founder mice developed a neurological disease that was characterized by loss of landing reflex, tremor, and ataxia. These neurological signs were observed as...

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Source

Identifiers

PMID: 11801633
DOI: 10.4049/jimmunol.168.3.1009

Genes

CCL21
CCL19

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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