Article
Implementation of high resolution single nucleotide polymorphism array analysis as a clinical test for patients with hematologic malignancies.
Cancer genetics - 1 Jan 2011
Dougherty Margaret J, Wilmoth Donna M, Tooke Laura S, Shaikh Tamim H, Gai Xiaowu, Hakonarson Hakon, Biegel Jaclyn A
Abstract excerpt
Single nucleotide polymorphism-based oligonucleotide arrays have been used as a research tool to detect genomic copy number changes and allelic imbalance in a variety of hematologic malignancies and solid tumors. The high resolution, genome-wide coverage, minimal DNA requirements, and relatively short turnaround time are advantageous for use in a clinical setting. We validated the Illumina HumanHap550 BeadChip...
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