Influence of TYK2 in systemic sclerosis susceptibility: a new locus in the IL-12 pathway.

doi:10.1136/annrheumdis-2015-208154

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Article

Influence of TYK2 in systemic sclerosis susceptibility: a new locus in the IL-12 pathway.

Annals of the rheumatic diseases - 1 Aug 2016

López-Isac Elena, Campillo-Davo Diana, Bossini-Castillo Lara, Guerra Sandra G, Assassi Shervin, Simeón Carmen Pilar, Carreira Patricia, Ortego-Centeno Norberto, García de la Peña Paloma, Beretta Lorenzo, Santaniello Alessandro, Bellocchi Chiara, Lunardi Claudio, Moroncini Gianluca, Gabrielli Armando, Riemekasten Gabriela, Witte Torsten, Hunzelmann Nicolas, Kreuter Alexander, Distler Jörg Hw, Voskuyl Alexandre E, de Vries-Bouwstra Jeska, Herrick Ariane, Worthington Jane, Denton Christopher P, Fonseca Carmen, Radstake Timothy Rdj, Mayes Maureen D, Martín Javier

Abstract excerpt

OBJECTIVES: TYK2 is a common genetic risk factor for several autoimmune diseases. This gene encodes a protein kinase involved in interleukin 12 (IL-12) pathway, which is a well-known player in the pathogenesis of systemic sclerosis (SSc). Therefore, we aimed to assess the possible role of this locus in SSc. METHODS: This study comprised a total of 7103 patients with SSc and 12 220 healthy controls of European...

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Source

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Identifiers

PMID: 26338038
DOI: 10.1136/annrheumdis-2015-208154
PMCID: PMC7228811

Genes

TYK2

Variants

rs2304256
rs2304256
rs2304256

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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