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Article

The aristaless-like homeobox protein Alx3 as an etiopathogenic factor for diabetes mellitus.

Islets - 1 Jan 2000

Vallejo Mario

Abstract excerpt

Inactivation of the gene encoding the aristaless-related homeodomain transcription factor Alx3 results in islet cell apoptosis and impaired glucose homeostasis that worsens with age due to the appearance of insulin resistance. Alx3-deficient mice also show extrapancreatic developmental defects with variable penetrance. These include polydactyly, craniofacial midline defects, and neural tube closure defects. In...

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Identifiers

PMID: 21350340
DOI: 10.4161/isl.3.2.14658

Genes

ALX3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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