Article
Homeobox gene Dlx3 is regulated by p63 during ectoderm development: relevance in the pathogenesis of ectodermal dysplasias.
Development (Cambridge, England) - 1 Jan 2007
Radoja Nadezda, Guerrini Luisa, Lo Iacono Nadia, Merlo Giorgio R, Costanzo Antonio, Weinberg Wendy C, La Mantia Girolama, Calabrò Viola, Morasso Maria I
Abstract excerpt
Ectodermal dysplasias (EDs) are a group of human pathological conditions characterized by anomalies in organs derived from epithelial-mesenchymal interactions during development. Dlx3 and p63 act as part of the transcriptional regulatory pathways relevant in ectoderm derivatives, and autosomal mutations in either of these genes are associated with human EDs. However, the functional relationship between both...
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