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Article

The UCHL1 S18Y polymorphism and Parkinson's disease in a Japanese population.

Parkinsonism & related disorders - 1 Jul 2011

Snapinn Katherine W, Larson Eric B, Kawakami Hideshi, Ujike Hiroshi, Borenstein Amy R, Izumi Yuishin, Kaji Ryuji, Maruyama Hirofumi, Mata Ignacio F, Morino Hiroyuki, Oda Masaya, Tsuang Debby W, Yearout Dora, Edwards Karen L, Zabetian Cyrus P

Abstract excerpt

UCHL1 plays an important role in the ubiquitin-proteasome system and is a biologically plausible candidate gene for Parkinson's disease (PD). However, results from genetic association studies of the UCHL1 S18Y polymorphism have been equivocal. Meta-analyses indicate that the polymorphism's risk effect might be restricted to Asian populations and early-onset disease. To further explore the role of UCHL1 in PD, we...

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Source

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Identifiers

PMID: 21345711
DOI: 10.1016/j.parkreldis.2011.01.019
PMCID: PMC3119730

Genes

UCHL1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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