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Article

Lack of evidence for an association between UCHL1 S18Y and Parkinson's disease.

European journal of neurology - 1 Feb 2008

Hutter Carolyn M, Samii Ali, Factor Stewart A, Nutt John G, Higgins Donald S, Bird Thomas D, Griffith Alida, Roberts John W, Leis Berta C, Montimurro Jennifer S, Kay Denise M, Edwards Karen L, Payami Haydeh, Zabetian Cyrus P

Abstract excerpt

UCHL1 has been proposed as a candidate gene for Parkinson's disease (PD). A meta-analysis of white and Asian subjects reported an inverse association between the non-synonymous UCHL1 S18Y polymorphism and PD risk. However, this finding was not replicated in a large case-control study and updated meta-analysis restricted to white subjects. We performed a case-control study of 1757 PD patients recruited from...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18093156
DOI: 10.1111/j.1468-1331.2007.02012.x
PMCID: PMC2823263

Genes

UCHL1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence.

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Lack of evidence for an association between UCHL1 S18Y and Parkinson's disease.PMID 18093156Read ↗

UCHL-1 is not a Parkinson's disease susceptibility gene.Semantic proximity Read ↗

Lack of association between UCHL1 S18Y gene polymorphism and Parkinson's disease in the Asian population: a meta-analysis.Semantic proximity Read ↗

The UCHL1 S18Y polymorphism and Parkinson's disease in a Japanese population.Semantic proximity Read ↗

Lack of evidence for association of a UCH-L1 S18Y polymorphism with Parkinson's disease in a Han-Chinese population.Semantic proximity Read ↗

Association between ubiquitin carboxy-terminal hydrolase-L1 S18Y variant and risk of Parkinson's disease: the impact of ethnicity and onset age.Semantic proximity Read ↗

UCHL1 S18Y variant is a risk factor for Parkinson's disease in Japan.Semantic proximity Read ↗

UCHL1 is a Parkinson's disease susceptibility gene.Semantic proximity Read ↗

Case-control study of UCHL1 S18Y variant in Parkinson's disease.Semantic proximity Read ↗

Association between the ubiquitin carboxyl-terminal esterase L1 gene (UCHL1) S18Y variant and Parkinson's Disease: a HuGE review and meta-analysis.Semantic proximity Read ↗

Case-control study of the UCH-L1 S18Y variant in sporadic Parkinson's disease in the Chinese population.Semantic proximity Read ↗

Analysis of the UCHL1 genetic variant in Parkinson's disease among Chinese.Semantic proximity Read ↗

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