Article
Case-control study of the UCH-L1 S18Y variant in sporadic Parkinson's disease in the Chinese population.
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia - 1 Apr 2011
Wang Lei, Guo Ji-feng, Nie Li-luo, Luo Linzi, Zuo Xing, Shen Lu, Jiang Hong, Yan Xin-xiang, Xia Kun, Pan Qian, Tang Bei-sha
Abstract excerpt
The ubiquitin carboxy-terminal hydrolase L1 gene (UCH-L1) has been implicated in the etiology of Parkinson's disease (PD). In several previous studies, an S18Y (C54A) polymorphism in exon 3 of the UCH-L1 gene has been found to be protective against PD. We performed polymerase chain reaction-restriction fragment length polymorphism analysis for DNA samples from 408 Chinese patients with PD and 398 Chinese healthy...
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