Article
Identification of putative residues involved in the accessibility of the substrate-binding site of lipoxygenase by site-directed mutagenesis studies.
Archives of biochemistry and biophysics - 1 May 2011
Palmieri-Thiers Cynthia, Alberti Jean-Christophe, Canaan Stéphane, Brunini Virginie, Gambotti Claude, Tomi Félix, Oliw Ernst H, Berti Liliane, Maury Jacques
Abstract excerpt
Lipoxygenases (LOXs) are a class of widespread dioxygenases catalyzing the hydroperoxidation of polyunsaturated fatty acids (PUFA). Recently, we isolated a cDNA encoding a LOX, named olive LOX1, from olive fruit of which the deduced amino acid sequence shows more than 50% identity with plant LOXs. In the present study, a model of olive LOX1 based on the crystal structure of soybean LOX-1 as template has been...
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