Article
Comparative genome sequencing of an isogenic pair of USA800 clinical methicillin-resistant Staphylococcus aureus isolates obtained before and after daptomycin treatment failure.
Antimicrobial agents and chemotherapy - 1 May 2011
Boyle-Vavra Susan, Jones Marcus, Gourley Brett L, Holmes Michael, Ruf Rebecca, Balsam Ashley R, Boulware David R, Kline Susan, Jawahir Selina, Devries Aaron, Peterson Scott N, Daum Robert S
Abstract excerpt
We describe here a clinical daptomycin treatment failure in a patient with recurrent methicillin-resistant Staphylococcus aureus (MRSA) bacteremia in whom daptomycin was administered after a failed empirical treatment course with vancomycin and piperacillin-tazobactam. We had the opportunity to compare the genome sequences of an isogenic pair of daptomycin-susceptible and -resistant MRSA isolates obtained before...
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