Article
Pro-inflammatory cytokine/chemokine production by reovirus treated melanoma cells is PKR/NF-κB mediated and supports innate and adaptive anti-tumour immune priming.
Molecular cancer - 21 Feb 2011
Steele Lynette, Errington Fiona, Prestwich Robin, Ilett Elizabeth, Harrington Kevin, Pandha Hardev, Coffey Matt, Selby Peter, Vile Richard, Melcher Alan
Abstract excerpt
BACKGROUND: As well as inducing direct oncolysis, reovirus treatment of melanoma is associated with activation of innate and adaptive anti-tumour immune responses. RESULTS: Here we characterise the effects of conditioned media from reovirus-infected, dying human melanoma cells (reoTCM), in the absence of live virus, to address the immune bystander potential of reovirus therapy. In addition to RANTES, IL-8, MIP-1α...
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