Article
Engineered Amp C β-lactamase as a fluorescent screening tool for class C β-lactamase inhibitors.
Analytical chemistry - 15 Mar 2011
Tsang Man-Wah, Chan Pak-Ho, So Pui-Kin, Ma Dik-Lung, Tsang Chun-Wai, Wong Kwok-Yin, Leung Yun-Chung
Abstract excerpt
Class C β-lactamases mediate antibiotic resistance in bacteria by efficiently hydrolyzing a broad range of β-lactam antibiotics. With their clinical significance and the lack of commercially available effective inhibitors, development of class C β-lactamase inhibitors has become one of the recent...
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