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Article

A novel fluorescent probe for the detection of AmpC beta-lactamase and the application in screening beta-lactamase inhibitors.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy - 15 Jun 2020

Yu Pan, Yang Jia-Ning, Yan Jin-Wu, Meng Zhi-Zhong, Hong W David, Roberts Adam P, Ward Stephen A, Zhang Lei, Li Shan

Abstract excerpt

The rapid detection of β-lactamases (Blas) and effective screening of Bla inhibitors are critically important and urgent for solving antibiotic resistance and improving precision medicine. Here a novel fluorescent probe CDC-559 was designed and synthesized, which can be used for the selective and direct detection of AmpC Blas. More importantly, it can realize screening the Bla inhibitors with sulbactam sodium and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32208355
DOI: 10.1016/j.saa.2020.118257

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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