Article
Association of genetic variants of the histamine H1 and muscarinic M3 receptors with BMI and HbA1c values in patients on antipsychotic medication.
Psychopharmacology - 1 Jul 2011
Vehof Jelle, Risselada Arne J, Al Hadithy Asmar F Y, Burger Huibert, Snieder Harold, Wilffert Bob, Arends Johan, Wunderink Lex, Knegtering Henrikus, Wiersma Durk, Cohen Dan, Mulder Hans, Bruggeman Richard
Abstract excerpt
RATIONALE: Antipsychotic affinity for the histamine H1 receptor and the muscarinic M3 receptor have been associated with the side effects weight gain, and development of diabetes, respectively. OBJECTIVES: We investigated polymorphisms of the histamine H1 (HRH1) and muscarinic acetylcholine receptor M3 (CHRM3) receptor genes for an association with body mass index (BMI) and glycated hemoglobin (HbA1c). METHODS:...
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