Article
Cholesterol accumulates in senile plaques of Alzheimer disease patients and in transgenic APP(SW) mice.
Journal of neuropathology and experimental neurology - 1 Aug 2001
Mori T, Paris D, Town T, Rojiani A M, Sparks D L, Delledonne A, Crawford F, Abdullah L I, Humphrey J A, Dickson D W, Mullan M J
Abstract excerpt
Mounting evidence suggests that cholesterol may contribute to the pathogenesis of Alzheimer disease (AD). We examined whether cholesterol might be present in senile plaques, a hallmark neuropathological feature of AD. We employed 2 different fluorometric-staining techniques (filipin staining and an enzymatic technique) for the determination of cholesterol in brains of postmortem confirmed AD patients and in...
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