Article
Low frequency of the APP 670/671 mutation in familial Alzheimer's disease in Sweden.
Neuroscience letters - 16 Apr 1993
Lannfelt L, Viitanen M, Johansson K, Axelman K, Lilius L, Almqvist E, Winblad B
Abstract excerpt
Molecular genetic studies have identified disease-causing mutations at codon 717 of the amyloid protein precursor gene in families with early-onset Alzheimer's disease. Recently, we reported a new mutation at codon 670/671 in a large Swedish family with Alzheimer's disease. The mutation results in two amino acid changes at the N-terminal of the beta-amyloid region. In the present study, we screened for the APP...
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