Article
Low frequency of the APP 670/671 mutation in familial Alzheimer's disease in Sweden.
Neuroscience letters - 16 Apr 1993
Lannfelt L, Viitanen M, Johansson K, Axelman K, Lilius L, Almqvist E, Winblad B
Abstract excerpt
Molecular genetic studies have identified disease-causing mutations at codon 717 of the amyloid protein precursor gene in families with early-onset Alzheimer's disease. Recently, we reported a new mutation at codon 670/671 in a large Swedish family with Alzheimer's disease. The mutation results i...
Topics
- Alzheimer Disease
- Amyloid beta-Protein Precursor
- Base Sequence
- Codon
- Gene Frequency
- Humans
- Molecular Probes
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- Sweden