Genomic Exploration of Essential Hypertension in African-Brazilian Quilombo Populations: A Comprehensive Approach With Pedigree Analysis and Family-Based Association Studies.

Abstract excerpt

BACKGROUND: Essential hypertension (EH) is a global health issue. Despite extensive research, much of EH heritability remains unexplained. We investigated the genetic basis of EH in African-derived individuals from partially isolated quilombo populations in Vale do Ribeira (São Paulo, Brazil). METHODS AND RESULTS: Samples from 431 individuals (167 affected, 261 unaffected, 3 unknown) were genotyped using a 650...

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