Is the ACE I/D polymorphism associated with extreme longevity? A study on a Spanish cohort.

doi:10.1177/1470320310391505

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Is the ACE I/D polymorphism associated with extreme longevity? A study on a Spanish cohort.

Journal of the renin-angiotensin-aldosterone system : JRAAS - 1 Sept 2011

Fiuza-Luces Carmen, Ruiz Jonatan R, Rodríguez-Romo Gabriel, Santiago Catalina, Gómez-Gallego Félix, Cano-Nieto Amalia, Garatachea Nuria, Rodríguez-Moreno Inmaculada, Morán María, Lucia Alejandro

Abstract excerpt

The 287 bp Ins(I)/Del(D) polymorphism [rs1799752] in intron 16 of the angiotensin-converting enzyme (ACE) gene has been associated with extreme longevity (≥ 100 years) in some Caucasian and Asian cohorts, but this finding was not corroborated in other reports. We compared the allelic/genotypic frequency of the ACE I/D polymorphism among centenarians (N = 64, 100-108 years, 89.1% female) and nonagenarians (N = 47,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged, 80 and over

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cohort Studies

Share to Genetic Association Studies

Share to Genotyping Techniques

Share to INDEL Mutation

Share to Longevity

Share to Peptidyl-Dipeptidase A

Share to Spain

Source

Open in PubMed

Identifiers

PMID: 21330423
DOI: 10.1177/1470320310391505

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Is the ACE I/D polymorphism associated with extreme longevity? A study on a Spanish cohort.PMID 21330423Read ↗

The ACE DD genotype and D-allele are associated with exceptional longevity: a meta-analysis.Semantic proximity Read ↗

Artificial intelligence-assisted meta-analysis of the frequency of<i>ACE</i>I/D polymorphisms in centenarians and other long-lived individualsSemantic proximity Read ↗

Angiotensin-converting enzyme deletion allele is beneficial for the longevity of Europeans.Semantic proximity Read ↗

Artificial Intelligence-Assisted Meta-Analysis of the Frequency of ACE I/D Polymorphisms in Centenarians and Other Long-Lived Individuals.Semantic proximity Read ↗

Angiotensin-Converting Enzyme (ACE) genetic variation and longevity in Peruvian older people: a cross-sectional study.Semantic proximity Read ↗

Sex differences in the association of apolipoprotein E and angiotensin-converting enzyme gene polymorphisms with healthy aging and longevity: a population-based study from Southern Italy.Semantic proximity Read ↗

Angiotensin I converting enzyme (ACE) gene polymorphism in centenarians: different allele frequencies between the North and South of Europe.Semantic proximity Read ↗

Angiotensin converting enzyme insertion/deletion polymorphism in sporadic and familial Alzheimer's disease and longevity.Semantic proximity Read ↗

Analysis of common polymorphisms in angiotensin-converting enzyme and apolipoprotein e genes and human longevity in Colombia.Semantic proximity Read ↗

Alzheimer disease risk and genetic variation in ACE: a meta-analysis.Semantic proximity Read ↗

The ApoE gene is related with exceptional longevity: a systematic review and meta-analysis.Semantic proximity Read ↗

ApoE gene and exceptional longevity: Insights from three independent cohorts.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.