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Article

Aldose reductase-mediated induction of epithelium-to-mesenchymal transition (EMT) in lens.

Chemico-biological interactions - 30 May 2011

Zablocki Gregory J, Ruzycki Philip A, Overturf Michelle A, Palla Suryanarayana, Reddy G Bhanuprakesh, Petrash J Mark

Abstract excerpt

Cataract is a key factor in the morbidity associated with diabetes. While the pathogenesis of diabetic cataract formation is poorly understood, previous research has identified aldose reductase (ALR2) as a key player. To elucidate a potential role for this enzyme in diabetic cataract formation, we created a series of transgenic mice designed for expression of human ALR2 (AKR1B1) in epithelial and outer cortical...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Gene Expression Regulation, Enzymologic

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Source

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Identifiers

PMID: 21329682
DOI: 10.1016/j.cbi.2011.02.005
PMCID: PMC3575513

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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