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Article

Integration of genotypic and phenotypic screening reveals molecular mediators of melanoma-stromal interaction.

Cancer research - 1 Apr 2011

Stine Megan J, Wang C Joanne, Moriarty Whei F, Ryu Byungwoo, Cheong Raymond, Westra William H, Levchenko Andre, Alani Rhoda M

Abstract excerpt

Tumor-endothelium interactions are critical for tumor survival and metastasis. Melanomas can rapidly metastasize early in tumor progression, but the dependence of this aggressive behavior on tumor-stromal interaction is poorly understood. To probe the mechanisms involved, we developed a heterotypic coculture methodology, allowing simultaneous tracking of genomic and phenotypic changes in interacting tumor and...

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Identifiers

PMID: 21324919
DOI: 10.1158/0008-5472.CAN-10-1875
PMCID: PMC3070809

Genes

NRP2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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