Article
Down-regulation of granulocyte-macrophage colony-stimulating factor by 3C-like proteinase in transfected A549 human lung carcinoma cells.
BMC immunology - 17 Feb 2011
Liao Hsien-Hua, Wang Yao-Chen, Chen Miles Chih-Ming, Tsai Hsien-Yu, Lin Johnson, Chen Shui-Tein, Tsay Gregory Jiazer, Cheng Sun-Long
Abstract excerpt
BACKGROUND: Severe Acute Respiratory Syndrome (SARS) is a severe respiratory illness caused by a novel virus, the SARS coronavirus (SARS-CoV). 3C-like protease (3CLpro) of SARS-CoV plays a role in processing viral polypeptide precursors and is responsible of viral maturation. However, the function of 3CLpro in host cells remains unknown. This study investigated how the 3CLpro affected the secretion of cytokines...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.