Article
Activation of NF-kappaB by the full-length nucleocapsid protein of the SARS coronavirus.
Acta biochimica et biophysica Sinica - 1 Sept 2005
Liao Qing-Jiao, Ye Lin-Bai, Timani Khalid Amine, Zeng Ying-Chun, She Ying-Long, Ye Li, Wu Zheng-Hui
Abstract excerpt
The severe acute respiratory syndrome coronavirus (SARS-CoV) is the major causative agent for the worldwide outbreak of SARS in 2003. The mechanism by which SARS-CoV causes atypical pneumonia remains unclear. The nuclear factor kappa B (NF-kappaB) is a key transcription factor that activates numerous genes involved in cellular immune response and inflammation. Many studies have shown that NF-kappaB plays an...
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