Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effects of polymorphisms in ovine and caprine prion protein alleles on cell-free conversion.

Veterinary research - 15 Feb 2011

Eiden Martin, Soto Elizabeth Ortega, Mettenleiter Thomas C, Groschup Martin H

Abstract excerpt

In sheep polymorphisms of the prion gene (PRNP) at the codons 136, 154 and 171 strongly influence the susceptibility to scrapie and bovine spongiform encephalopathy (BSE) infections. In goats a number of other gene polymorphisms were found which are suspected to trigger similar effects. However, no strong correlation between polymorphisms and TSE susceptibility in goats has yet been obtained from epidemiological...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Substitution
Share to Brain
Share to Disease Susceptibility

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Goat Diseases

Share to Prions

Share to Scrapie

Source

Open in PubMed Open full text

Identifiers

PMID: 21324112
DOI: 10.1186/1297-9716-42-30
PMCID: PMC3050705

Genes

PRNP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effects of polymorphisms in ovine and caprine prion protein alleles on cell-free conversion.PMID 21324112Read ↗

Susceptibility of sheep for scrapie as assessed by in vitro conversion of nine naturally occurring variants of PrP.Semantic proximity Read ↗

Amino acid sequence and prion strain specific effects on the in vitro and in vivo convertibility of ovine/murine and bovine/murine prion protein chimeras.Semantic proximity Read ↗

Scrapie susceptibility-linked polymorphisms modulate the in vitro conversion of sheep prion protein to protease-resistant forms.Semantic proximity Read ↗

Influence of the prion protein gene, Prnp, on scrapie susceptibility in sheep.Semantic proximity Read ↗

Sheep scrapie susceptibility-linked polymorphisms do not modulate the initial binding of cellular to disease-associated prion protein prior to conversion.Semantic proximity Read ↗

Adaptation of a low-cost medium-throughput genotyping system for ovine prion protein gene polymorphims associated with scrapie.Semantic proximity Read ↗

The shortest known prion protein gene allele occurs in goats, has only three octapeptide repeats and is non-pathogenic.Semantic proximity Read ↗

Transmissible spongiform encephalopathy in goats: is PrP rapid test sensitivity affected by genotype?Semantic proximity Read ↗

Prion protein gene polymorphisms in Turkish native goat breeds.Semantic proximity Read ↗

Transmissibility of atypical scrapie in ovine transgenic mice: major effects of host prion protein expression and donor prion genotype.Semantic proximity Read ↗

Prion protein alleles showing a protective effect on the susceptibility of sheep to scrapie and bovine spongiform encephalopathy.Semantic proximity Read ↗

Functional and structural differences between the prion protein from two alleles prnp(a) and prnp(b) of mouse.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.