Article
IL28B genetic variations are associated with high sustained virological response (SVR) of interferon-α plus ribavirin therapy in Taiwanese chronic HCV infection.
Genes and immunity - 1 Jun 2011
Chen J-Y, Lin C-Y, Wang C-M, Lin Y-T, Kuo S-N, Shiu C-F, Chang S-W, Wu J, Sheen I-S
Abstract excerpt
Chronic hepatitis C virus (HCV) infection patients exhibit different sustained virological responses (SVRs) following the treatment with pegylated interferon-α (IFN-α) and ribavirin. Genome-wide association studies consistently linked SVR of IFN-α-based therapy to the IL28B single-nucleotide polymorphisms (SNPs) on chromosome 19q.13 in various populations. This study was undertaken to investigate the association...
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