Host interleukin-28B genetic variants versus viral kinetics in determining responses to standard-of-care for Asians with hepatitis C genotype 1.

doi:10.1016/j.antiviral.2011.12.002

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Host interleukin-28B genetic variants versus viral kinetics in determining responses to standard-of-care for Asians with hepatitis C genotype 1.

Antiviral research - 1 Feb 2012

Huang Chung-Feng, Yeh Ming-Lun, Huang Jee-Fu, Yang Jeng-Fu, Hsieh Ming-Yen, Lin Zu-Yau, Chen Shinn-Cherng, Wang Liang-Yen, Hsi Edward, Juo Suh-Hang Hank, Dai Chia-Yen, Chuang Wan-Long, Yu Ming-Lung

Abstract excerpt

BACKGROUND: Both interleukin-28B genetic variants and on-treatment virological responses are factors predictive of treatment outcome in hepatitis C virus genotype 1 (HCV-1) patients. We aimed to compare the clinical significance of the two factors. METHODS: Rs8099917 genotype and on-treatment responses were determined in 182 HCV-1 patients with 48-week peginterferon/ribavirin. RESULTS: Comparing to patients with...

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PMID: 22193282
DOI: 10.1016/j.antiviral.2011.12.002

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