Article
Identification of immunogenic regions within the alternative reading frame protein of hepatitis C virus (genotype 3).
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology - 1 Sept 2011
Qureshi H, Qazi R, Hamid S, Qureshi S A
Abstract excerpt
Hepatitis C virus (HCV) encodes ten classic proteins as well as a newly discovered alternative reading frame protein (ARFP) whose synthesis originates from the core region by a +1 frameshift. ARFP is produced by all HCV genotypes, but its function remains unknown. Although the immunogenicity of genotype 1- and 2-derived ARFP in infected hosts has been reported, no information is available for genotype 3-encoded...
Topics
- Adolescent
- Adult
- Amino Acid Sequence
- Antigens, Viral
- Base Sequence
- Cloning, Molecular
- Genotype
- Hepacivirus
- Hepatitis C Antibodies
- Humans
- Leukocytes, Mononuclear
- Middle Aged
- Molecular Sequence Data
- Recombinant Proteins
- Viral Core Proteins
- Young Adult