Article
Antigenic relevance of F protein in chronic hepatitis C virus infection.
Hepatology (Baltimore, Md.) - 1 Oct 2004
Komurian-Pradel Florence, Rajoharison Alain, Berland Jean-Luc, Khouri Valérie, Perret Magali, Van Roosmalen Mark, Pol Stanislas, Negro Francesco, Paranhos-Baccalà Glaucia
Abstract excerpt
The hepatitis C virus (HCV) F protein is a recently described, frameshift product of HCV core encoding sequence of genotype 1a. Its function and antigenic properties are unknown. Using enzyme-linked immunosorbent assay, we assessed the prevalence of anti-F antibodies in 154 patients chronically infected with HCV, 65 patients with other liver diseases, and 121 healthy controls. For this purpose, we expressed a...
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