Article
Recombinant expression of the alternate reading frame protein (ARFP) of hepatitis C virus genotype 4a (HCV-4a) and detection of ARFP and anti-ARFP antibodies in HCV-infected patients.
Archives of virology - 1 Aug 2015
Shehat Michael G, Bahey-El-Din Mohammed, Kassem Mervat A, Farghaly Faten A, Abdul-Rahman Medhat H, Fanaki Nourhan H
Abstract excerpt
HCV is a single-stranded RNA virus with a single open reading frame (ORF) that is translated into a polyprotein that is then processed to form 10 viral proteins. An additional eleventh viral protein, the alternative reading frame protein (ARFP), was discovered relatively recently. This protein results from a translational frameshift in the core region during the expression of the viral proteins. Recombinant...
Topics
- Adult
- Female
- Gene Expression
- Genotype
- Hepacivirus
- Hepatitis C
- Hepatitis C Antibodies
- Humans
- Male
- Middle Aged
- Recombinant Proteins
- Viral Core Proteins