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Article

Isoflurane reduces excitability of Drosophila larval motoneurons by activating a hyperpolarizing leak conductance.

Anesthesiology - 1 Mar 2008

Sandstrom David J

Abstract excerpt

BACKGROUND: Mechanisms of anesthetic-mediated presynaptic inhibition are incompletely understood. Isoflurane reduces presynaptic excitability at the larval Drosophila neuromuscular junction, slowing conduction velocity and depressing glutamate release. Mutations in the Para voltage-gated Na channel enhance anesthetic sensitivity of adult flies. Here, the author examines the role of para in anesthetic sensitivity...

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PMID: 18292681
DOI: 10.1097/ALN.0b013e318164cfda

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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