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Article

Fast- and slow-gating modes of the sodium channel are altered by a paramyotonia congenita-linked mutation.

Journal of bioenergetics and biomembranes - 1 Dec 1998

Moran O, Melani R, Nizzari M, Conti F

Abstract excerpt

We have studied the expression in frog oocytes of the alpha subunit of the rat skeletal muscle sodium channel mutation T1306M, homologous to the mutation T1313M of the human isoform that causes the muscular hereditary disease paramyotonia congenita. Wild-type (WT) channels show a bimodal behavior, with two gating modes characterized by inactivation time constants that differ at least by one order of magnitude and...

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Source

Identifiers

PMID: 10206477
DOI: 10.1023/a:1020536601658

Genes

PAM

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Fast- and slow-gating modes of the sodium channel are altered by a paramyotonia congenita-linked mutation.PMID 10206477Read ↗

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