Article
Human Na+ channel fast and slow inactivation in paramyotonia congenita mutants expressed in Xenopus laevis oocytes.
The Journal of physiology - 15 Mar 1997
Richmond J E, Featherstone D E, Ruben P C
Abstract excerpt
1. Paramyotonia congenita (PC) is a human hereditary disease caused by one or more amino acid substitutions in skeletal muscle sodium channels. Using macropatches, the effect of PC mutations R1448C and T1313M were compared with wild-type (WT) in Xenopus oocytes coinjected with both alpha- and beta-subunits of human skeletal muscle (SkM1) sodium channels. 2. Slow inactivation in either T1313M or R1448C was not...
Topics
- Action Potentials
- Animals
- Humans
- Ion Channel Gating
- Muscle, Skeletal
- Mutation
- Myotonia Congenita
- Oocytes
- Patch-Clamp Techniques
- Phenotype
- Recombinant Proteins
- Sodium Channels
- Transfection
- Xenopus laevis