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Article

UGT1A1, UGT1A6 and UGT1A7 genetic analysis: repercussion for irinotecan pharmacogenetics in the São Miguel Island Population (Azores, Portugal).

Molecular diagnosis & therapy - 1 Jan 2009

Pacheco Paula R, Brilhante Maria J, Ballart Cristina, Sigalat Francesc, Polena Helena, Cabral Rita, Branco Claudia C, Mota-Vieira Luisa

Abstract excerpt

BACKGROUND: Glucuronidation reactions, catalyzed by uridine-diphosphate glucuronosyltransferase (UGT) enzymes, constitute a detoxification process that adds glucuronic acid to endogenous and exogenous compounds, aiding their excretion. UGT1A proteins have been implicated as risk factors for both the development of cancer and adverse drug effects. METHODS: Here, we assess the genome of 469 individuals from São...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19712005
DOI: 10.2165/11317170-000000000-00000

Genes

UGT1A1
UGT1A7
UGT1A6

Provenance

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