Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Splicing factor polymorphisms, the control of VEGF isoforms and association with angiogenic eye disease.

Current eye research - 1 Apr 2011

Carter J G, Cherry J, Williams K, Turner S, Bates D O, Churchill A J

Abstract excerpt

PURPOSE: Alternative splicing of the last exon (exon 8) of vascular endothelial growth factor (VEGF) pre-mRNA is a key element in the balance of pro- and anti-angiogenic VEGF isoforms in exudative age-related macular degeneration (exAMD) and proliferative diabetic retinopathy (PDR). Three splicing factors, SRp40, ASF/SF2, and SRp55 are predicted to control alternative splicing by binding to exonic splice...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Choroidal Neovascularization
Share to Diabetic Retinopathy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Heteroduplex Analysis

Share to Macular Degeneration

Share to Pilot Projects

Share to Retinal Neovascularization

Share to Serine-Arginine Splicing Factors

Share to Vascular Endothelial Growth Factor A

Source

Identifiers

PMID: 21309690
DOI: 10.3109/02713683.2010.548892

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Splicing factor polymorphisms, the control of VEGF isoforms and association with angiogenic eye disease.PMID 21309690Read ↗

Identification of cis- and trans-acting genetic variants explaining up to half the variation in circulating vascular endothelial growth factor levels.Semantic proximity Read ↗

Topical Antiangiogenic SRPK1 Inhibitors Reduce Choroidal Neovascularization in Rodent Models of Exudative AMDSemantic proximity Read ↗

A tag-single nucleotide polymorphisms approach to the vascular endothelial growth factor-A gene in age-related macular degeneration.Semantic proximity Read ↗

Polymorphisms in the VEGFA and VEGFR-2 genes and neovascular age-related macular degeneration.Semantic proximity Read ↗

Stromal Cell-Derived Factor 1 Polymorphism in Retinal Vein Occlusion.Semantic proximity Read ↗

Mechanistic analysis of compounds that modulate VEGF-A splicing in podocytes with therapeutic potential for diabetic nephropathySemantic proximity Read ↗

PLP1 alternative splicing in differentiating oligodendrocytes: characterization of an exonic splicing enhancer.Semantic proximity Read ↗

FLT1 genetic variation predisposes to neovascular AMD in ethnically diverse populations and alters systemic FLT1 expression.Semantic proximity Read ↗

Evaluation of sFLT1 protein levels in human eyes with the FLT1 rs9943922 polymorphism.Semantic proximity Read ↗

A common 936 C/T mutation in the gene for vascular endothelial growth factor is associated with vascular endothelial growth factor plasma levels.Semantic proximity Read ↗

VEGF Spliced Variants: Possible Role of Anti-Angiogenesis TherapySemantic proximity Read ↗

The GG genotype of erythropoietin rs1617640 polymorphism affects the risk of proliferative diabetic retinopathy in Slovenian subjects with type 2 diabetes mellitus: enemy or ally?Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.