Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

PLP1 alternative splicing in differentiating oligodendrocytes: characterization of an exonic splicing enhancer.

Journal of cellular biochemistry - 1 Apr 2006

Wang Erming, Huang Zhong, Hobson Grace M, Dimova Neviana, Sperle Karen, McCullough Andrew, Cambi Franca

Abstract excerpt

Proteolipid protein (PLP) and DM20 are generated by alternative splicing of exon 3B of PLP1 transcript in differentiating oligodendrocytes. We investigated the role of exonic splicing enhancers (ESE) in the selection of PLP 5' donor site, focusing on putative ASF/SF2, and SC35 binding motifs in exon 3B on the basis of mutations that cause disease in humans. Mutations in a putative ASF/SF2 binding motif...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alternative Splicing
Share to Amino Acid Motifs

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cell Lineage

Share to Enhancer Elements, Genetic

Share to Myelin Proteolipid Protein

Share to Oligodendroglia

Share to Rats, Sprague-Dawley

Share to RNA Splice Sites

Source

Identifiers

PMID: 16288477
DOI: 10.1002/jcb.20692

Genes

PLP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

PLP1 alternative splicing in differentiating oligodendrocytes: characterization of an exonic splicing enhancer.PMID 16288477Read ↗

Splice-site contribution in alternative splicing of PLP1 and DM20: molecular studies in oligodendrocytes.Semantic proximity Read ↗

PMD patient mutations reveal a long-distance intronic interaction that regulates PLP1/DM20 alternative splicing.Semantic proximity Read ↗

Three new PLP1 splicing mutations demonstrate pathogenic and phenotypic diversity of Pelizaeus-Merzbacher disease.Semantic proximity Read ↗

Heterogeneous nuclear ribonucleoproteins H and F regulate the proteolipid protein/DM20 ratio by recruiting U1 small nuclear ribonucleoprotein through a complex array of G runs.Semantic proximity Read ↗

A PLP splicing abnormality is associated with an unusual presentation of PMD.Semantic proximity Read ↗

Disruption of an SF2/ASF-dependent exonic splicing enhancer in SMN2 causes spinal muscular atrophy in the absence of SMN1.Semantic proximity Read ↗

The role of U2AF35 and U2AF65 in enhancer-dependent splicing.Semantic proximity Read ↗

A de novo splice donor site mutation causes in-frame deletion of 14 amino acids in the proteolipid protein in Pelizaeus-Merzbacher disease.Semantic proximity Read ↗

Risk Allele rs117026326-Mediated Alternative Splicing of GTF2I Promotes B Cell Proliferation in Primary Sjögren's Syndrome.Semantic proximity Read ↗

Separate proteolipid protein/DM20 enhancers serve different lineages and stages of development.Semantic proximity Read ↗

Protein phosphatase 1 binds to the RNA recognition motif of several splicing factors and regulates alternative pre-mRNA processingSemantic proximity Read ↗

Alternative splicing of CD200 is regulated by an exonic splicing enhancer and SF2/ASF.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.