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Article

VEGF Spliced Variants: Possible Role of Anti-Angiogenesis Therapy

13 Oct 2011

Abstract excerpt

Angiogenesis has been targeted in retinopathies, psoriasis, and a variety of cancers (colon, breast, lung, and kidney). Among these tumour types, clear cell renal cell carcinomas (RCCs) are the most vascularized tumours due to mutations of the von Hippel Lindau gene resulting in HIF-1 alpha stabilisation and overexpression of Vascular Endothelial Growth Factor (VEGF). Surgical nephrectomy remains the most...

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Identifiers

PMID: 22013509
DOI: 10.1155/2012/162692

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