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Article

KCNJ6 is associated with adult alcohol dependence and involved in gene × early life stress interactions in adolescent alcohol drinking.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 May 2011

Clarke Toni-Kim, Laucht Manfred, Ridinger Monika, Wodarz Norbert, Rietschel Marcella, Maier Wolfgang, Lathrop Mark, Lourdusamy Anbarasu, Zimmermann Ulrich S, Desrivieres Sylvane, Schumann Gunter

Abstract excerpt

Alcohol abuse and dependence have proven to be complex genetic traits that are influenced by environmental factors. Primate and human studies have shown that early life stress increases the propensity for alcohol abuse in later life. The reinforcing properties of alcohol are mediated by dopaminergic signaling; however, there is little evidence to indicate how stress alters alcohol reinforcement. KCNJ6 (the gene...

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Identifiers

PMID: 21307845
DOI: 10.1038/npp.2010.247
PMCID: PMC3079832

Genes

KCNJ6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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