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Article

A pathobiological role of the insulin receptor in chronic lymphocytic leukemia.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 May 2011

Saiya-Cork Kamlai, Collins Roxane, Parkin Brian, Ouillette Peter, Kuizon Erlene, Kujawski Lisa, Erba Harry, Campagnaro Erica, Shedden Kerby, Kaminski Mark, Malek Sami N

Abstract excerpt

PURPOSE: The chromosomal deletion 11q affects biology and clinical outcome in chronic lymphocytic leukemia (CLL) but del11q-deregulated genes remain incompletely characterized. EXPERIMENTAL DESIGN: We have employed integrated genomic profiling approaches on CLL cases with and without del11q to identify 11q-relevant genes. RESULTS: We have identified differential expression of the insulin receptor (INSR) in CLL,...

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Share to Chromosomes, Human, Pair 11
Share to Comparative Genomic Hybridization

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytogenetic Analysis

Share to Gene Expression Regulation, Leukemic

Share to Leukemia, Lymphocytic, Chronic, B-Cell

Share to Microarray Analysis

Share to Receptor, Insulin

Share to Validation Studies as Topic

Source

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Identifiers

PMID: 21307146
DOI: 10.1158/1078-0432.CCR-10-2058
PMCID: PMC3086966

Genes

INSR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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