Insulin growth factor 1 receptor expression is associated with NOTCH1 mutation, trisomy 12 and aggressive clinical course in chronic lymphocytic leukaemia.

doi:10.1371/journal.pone.0118801

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Article

Insulin growth factor 1 receptor expression is associated with NOTCH1 mutation, trisomy 12 and aggressive clinical course in chronic lymphocytic leukaemia.

PloS one - 1 Jan 2015

Maura Francesco, Mosca Laura, Fabris Sonia, Cutrona Giovanna, Matis Serena, Lionetti Marta, Agnelli Luca, Barbieri Marzia, D'Anca Marianna, Manzoni Martina, Colombo Monica, Massucco Carlotta, Reverberi Daniele, Gentile Massimo, Recchia Anna Grazia, Bossio Sabrina, Ilariucci Fiorella, Musolino Caterina, Di Raimondo Francesco, Cortelezzi Agostino, Morabito Fortunato, Ferrarini Manlio, Neri Antonino

Abstract excerpt

IGF1R is emerging as an important gene in the pathogenesis of many solid and haematological cancers and its over-expression has been reported as frequently associated with aggressive disease and chemotherapy resistance. In this study we performed an investigation of the role of IGF1R expression in a large and representative prospective series of 217 chronic lymphocytic leukaemia (CLL) patients enrolled in the...

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Identifiers

PMID: 25786252
DOI: 10.1371/journal.pone.0118801
PMCID: PMC4365018

Genes

NOTCH1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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