Article
Natural genetic variation in yeast longevity.
Genome research - 1 Oct 2012
Stumpferl Stefan W, Brand Sue E, Jiang James C, Korona Boguslawa, Tiwari Anurag, Dai Jianliang, Seo Jae-Gu, Jazwinski S Michal
Abstract excerpt
The genetics of aging in the yeast Saccharomyces cerevisiae has involved the manipulation of individual genes in laboratory strains. We have instituted a quantitative genetic analysis of the yeast replicative lifespan by sampling the natural genetic variation in a wild yeast isolate. Haploid segregants from a cross between a common laboratory strain (S288c) and a clinically derived strain (YJM145) were subjected...
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